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Heteroaromatic Lipoxin A4 Analogues

Name: Heteroaromatic Lipoxin A4 Analogues
Brand: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
SKU: 01659048
Price: 102.33 EUR
Availability: InStock
Author: Colm Duffy
ISBN: 9783642246319

Synthesis and Biological Evaluation

Colm Duffy

Language

English

Book Hardback

Libristo code: 01659048

Publishers Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, December 2011

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has pr... Full description

Libristo code: 01659048

249 b

102.33 €

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In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.