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Molecular Recognition

Name: Molecular Recognition
Brand: Nova Science Publishers Inc
SKU: 06434750
Price: 128.0 EUR
Availability: InStock
Author: F S Dukhovich
ISBN: 9781590338872

Pharmacological Aspects

F S Dukhovich

Language

English

Book Hardback

Libristo code: 06434750

Publishers Nova Science Publishers Inc, March 2004

In the monograph recognition of the receptors by drugs is described as a complex phenomenon that has... Full description

Libristo code: 06434750

310 b

128.00 €

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In the monograph recognition of the receptors by drugs is described as a complex phenomenon that has not been yet entirely understood. The description of molecular structure information necessary to achieve specific receptor without getting lost among huge amounts of non-specific acceptors is present. Various examples of receptor'' binding features for narcotic analgetics, neuroleptics, tranquilisators, ligands of acetylcholine receptors. The three stages of drug interaction with acceptors are considered, namely, distant stage, stage of orientation of the molecule on the acceptor, stage of molecule fixation. Kinetics and thermodynamics of these stages as well as factors preventing drug binding to non-specific acceptors are described. Some considerations concerning methods of changing activity and selectivity of drugs are given. Literature information needed for analysis of molecular mechanisms of interactions between drugs and receptors is present.