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Polymorphismus der Th17-Zytokin-Gene

Language GermanGerman
Book Paperback
Book Polymorphismus der Th17-Zytokin-Gene Sawsan Feki
Libristo code: 49027430
Publishers Verlag Unser Wissen, June 2025
Colitis ulcerosa (UC) und Morbus Cohn (MC), die beiden Hauptformen der chronisch-entzündlichen Darme... Full description
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54.39 €
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Colitis ulcerosa (UC) und Morbus Cohn (MC), die beiden Hauptformen der chronisch-entzündlichen Darmerkrankungen (CED), entstehen durch eine inadäquate Immunantwort gegenüber der Darmflora bei einem genetisch prädisponierten Individuum in Anwesenheit von Umweltfaktoren. CED ist ein komplexes Krankheitsbild, das mit einer chronischen Entzündung des Darms einhergeht, an der T-Helfer-Lymphozyten (LTh) stark beteiligt zu sein scheinen.Derzeit wird die Th17-Subpopulation als Hauptakteur der lokalen Entzündung durch entzündungsfördernde Zytokine (IL 17, 21 und 22) beschrieben. IL-17A und IL-17F sind die beiden wichtigsten Effektorzytokine und teilen sich mehr als 50% Homologie in Bezug auf die Aminosäuresequenz. Die entsprechenden Gene sind nahe beieinander auf dem kurzen Arm von Chromosom 6 (6p12) lokalisiert. Wir untersuchten den genetischen Polymorphismus von 2 Genen, die am Th17-Signalweg beteiligt sind: IL-17A (rs3748067) und IL-17F (rs763780) bei einer Gruppe von tunesischen IBD-Patienten im Vergleich zu einer Kontrollgruppe.

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About the book

Full name Polymorphismus der Th17-Zytokin-Gene
Author Sawsan Feki, Hatem Masmoudi
Language German
Binding Book - Paperback
Date of issue 2025
Number of pages 64
EAN 9786208972349
ISBN 6208972345
Libristo code 49027430
Publishers Verlag Unser Wissen
Weight 113
Dimensions 150 x 220 x 4

Categories

Medicine & Nursing > Medicine: general issues
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