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Statistical Methods for CGH Array Analysis

Language EnglishEnglish
Book Paperback
Book Statistical Methods for CGH Array Analysis Pei Wang
Libristo code: 06820282
Publishers VDM Verlag, February 2010
Genomic DNA copy number alterations are key genetic events in the initiation and progression of huma... Full description
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Genomic DNA copy number alterations are key genetic events in the initiation and progression of human cancers. Recent advance in the technique of microarray comparative genomic hybridization (array CGH) enables one to screen genome-wide for all possible regions with DNA copy number alterations, such as chromosome gains and losses, or localized amplifications and deletions. In this book, we introduce two statistical methods addressing two different questions for the data analysis of array CGH. The first method---Cluster Along Chromosomes--- is developed for calling gains and losses in CGH arrays. The second method--- Boosted PRIM (Patient Rule Induction Method)--- is developed to search for oncogenic pathways using array-CGH data. The performance of the methods are illustrated through both simulation studies and real applications.

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About the book

Full name Statistical Methods for CGH Array Analysis
Author Pei Wang
Language English
Binding Book - Paperback
Date of issue 2010
Number of pages 38
EAN 9783639114065
ISBN 363911406X
Libristo code 06820282
Publishers VDM Verlag
Weight 68
Dimensions 152 x 229 x 2

Categories

Mathematics & Science > Mathematics > Probability & statistics
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